Phenylpropanolamine Production Cost
The latest report titled “Phenylpropanolamine Production” by Procurement Resource, a global procurement research and consulting firm, provides an in-depth cost analysis of the production process of Phenylpropanolamine.
Procurement Resource study is based on the latest prices and other economic data available. It also offers additional analysis of the report with detailed breakdown of all cost components (capital investment details, production cost details, economics for another plant location, dynamic cost model). In addition, the report incorporates the production process with detailed process and material flow, capital investment, operating costs along with financial expenses and depreciation charges.
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Procurement Resource’s detailed report describes the stepwise consumption of material and utilities along with a detailed process flow diagram. Furthermore, the study assesses the latest developments within the industry that might influence Phenylpropanolamine production cost, looking into capacity expansions, plant turnarounds, mergers, acquisitions, and investments.
Procurement Resource Assessment of Phenylpropanolamine Production Process:
- From Catalytic Hydrogenation Reaction: This report presents the detailed production methodology and cost analysis of Phenylpropanolamine industrial production across Phenylpropanolamine manufacturing plants.The production process starts with benzaldehyde and nitroethane undergoing a chemical reaction in an alcoholic medium, typically 95% ethanol, with sodium hydroxide as a catalyst. This reaction yields α-(1-nitroethyl) benzyl alcohol as an intermediate product. The intermediate is then subjected to catalytic hydrogenation, where the nitro-alcohol is reduced to its corresponding amine. This step involves hydrogenating α-(1-nitroethyl) benzyl alcohol in the presence of a metal catalyst, like platinum, resulting in the formation of phenylpropanolamine as the end product.
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Product Definition:
Phenylpropanolamine, with the chemical formula C9H13NO, is a white crystalline powder with a faint aromatic scent. It consists of nine carbon, thirteen hydrogen, one nitrogen, and one oxygen atom, weighing 151.21 g/mol. Its melting point falls between 101-101.5 °C, and it readily dissolves in water and alcohols like ethanol, while being moderately soluble in isopropanol. However, it exhibits high insolubility in solvents such as benzene, chloroform, ethyl acetate, carbon tetrachloride, and ether. Structurally resembling pseudoephedrine, another drug used for nasal congestion, phenylpropanolamine belongs to the amine class and is synthesized by reducing the nitro-group in α-(1-nitroethyl) benzyl alcohol through catalytic hydrogenation. While stable under normal conditions, it decomposes when heated, releasing toxic nitroxide fumes. Considered a sympathomimetic agent, it finds use in the chemical and pharmaceutical industries, primarily in medications for cold symptoms and as an appetite suppressant. It is also combined with guaifenesin in cold-and-cough medicines to alleviate nasal congestion.
Market Drivers:
The global market for phenylpropanolamine is primarily fueled by its significant demand as a pharmaceutical drug. Its procurement is largely driven by its role as a crucial ingredient in pharmaceuticals. Its use as a key component in medications for treating cold and cough is a major driver of its global demand. Additionally, its appetite suppressant properties in certain medications contribute to its popularity in the pharmaceutical sector. The rising utilization of phenylpropanolamine in cold medications further enhances its demand. As a result, fluctuations in its demand as a pharmaceutical drug directly impact its procurement process.
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