The latest report titled “Ethacrynic Acid Production” by Procurement Resource, a global procurement research and consulting firm, provides an in-depth cost analysis of the production process of Ethacrynic Acid.
Procurement Resource study is based on the latest prices and other economic data available. It also offers additional analysis of the report with detailed breakdown of all cost components (capital investment details, production cost details, economics for another plant location, dynamic cost model). In addition, the report incorporates the production process with detailed process and material flow, capital investment, operating costs along with financial expenses and depreciation charges.
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Procurement Resource’s detailed report describes the stepwise consumption of material and utilities along with a detailed process flow diagram. Furthermore, the study assesses the latest developments within the industry that might influence Ethacrynic Acid production cost, looking into capacity expansions, plant turnarounds, mergers, acquisitions, and investments.
Procurement Resource Assessment of Ethacrynic Acid Production Process:
- From 2,3-Dichlorophenoxyacetic Acid: This report presents the detailed production methodology and cost analysis of Ethacrynic Acid industrial production across Ethacrynic Acid manufacturing plants. The production of ethacrynic acid starts with a reaction between 2,3-dichlorophenoxyacetic acid and butyroyl chloride, leading to the acylation of 2,3-dichlorophenoxyacetic acid to form 4-butyroyl-2,3-dichlorophenoxyacetic acid as an intermediate product. This intermediate then undergoes a Mannich reaction with dimethylamine and formaldehyde, followed by heating to induce degradation, culminating in the creation of ethacrynic acid as the final product.
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Product Definition:
Ethacrynic acid is a potent diuretic medication primarily used to treat fluid retention (edema) associated with conditions like congestive heart failure, liver cirrhosis, and renal disease. Unlike other diuretics, ethacrynic acid belongs to a class known as loop diuretics, which work by inhibiting the sodium-potassium-chloride cotransporter in the ascending limb of the loop of Henle in the kidneys. This action prevents water reabsorption, leading to increased urine production and a reduction in fluid buildup in the body. Ethacrynic acid is particularly useful in cases where patients are intolerant to sulfa drugs, which are common in other loop diuretics. Despite its effectiveness, ethacrynic acid is generally reserved for situations where other diuretics are ineffective or contraindicated due to its potential side effects, including electrolyte imbalance and hearing loss. Its unique mechanism and application make it an important, though specialized, tool in managing edema.
Market Drivers:
The market for ethacrynic acid is driven by several factors related to its medical applications and the prevalence of conditions requiring diuretic intervention. Firstly, the increasing incidence of diseases such as congestive heart failure, renal disorders, and hypertension contributes to the demand for effective diuretic treatments, including ethacrynic acid. Its utility in patients who are intolerant to sulfa-based diuretics further elevates its importance in clinical settings, providing a viable alternative for a subset of patients. Additionally, the growing elderly population, which is more susceptible to conditions like edema and heart failure, also boosts the demand for such medications. Advances in healthcare infrastructure and increased access to medical care in emerging economies expand the market for ethacrynic acid. However, the availability of newer, potentially safer diuretics may impact its market position, making ongoing research and development efforts crucial for maintaining its relevance in the pharmaceutical landscape.
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