The latest report titled “Chloramphenicol Production” by Procurement Resource, a global procurement research and consulting firm, provides an in-depth cost analysis of the production process of Chloramphenicol.
Procurement Resource study is based on the latest prices and other economic data available. It also offers additional analysis of the report with detailed breakdown of all cost components (capital investment details, production cost details, economics for another plant location, dynamic cost model). In addition, the report incorporates the production process with detailed process and material flow, capital investment, operating costs along with financial expenses and depreciation charges.
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Procurement Resource’s detailed report describes the stepwise consumption of material and utilities along with a detailed process flow diagram. Furthermore, the study assesses the latest developments within the industry that might influence Chloramphenicol production cost, looking into capacity expansions, plant turnarounds, mergers, acquisitions, and investments.
Procurement Resource Assessment of Chloramphenicol Production Process:
- From Fermentation Method: This report presents the detailed production methodology and cost analysis of Chloramphenicol industrial production across Chloramphenicol manufacturing plants. The manufacturing process involves fermenting a substrate with Streptomyces venezuelae, which may contain components like inorganic salts (e.g., magnesium sulfate), along with carbon and nitrogen sources. The fermentation activity of the bacterium results in the production of a filtrate. This filtrate undergoes extraction, filtration, and crystallization processes to yield chloramphenicol as the final product.
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Product Definition:
Chloramphenicol is a chemical entity characterized by its structure, consisting of eleven carbon atoms, twelve hydrogen atoms, two chlorine atoms, two nitrogen atoms, and five oxygen atoms, with a molecular formula of C11H12Cl2N2O5 and a molecular weight of 323.13 g/mol. This organochlorine compound, derived from the Streptomyces venezuelae bacterium, features a nitrobenzene ring with a dichloro-substituted acetamide group, an amide bond, and two hydroxyl groups. It appears as a white crystalline solid with a bitter flavor.The compound has a melting point of around 150.5 °C and transitions directly from solid to gas (sublimation) when heated above this temperature. Chloramphenicol is soluble in water and exhibits high solubility in alcohols such as methanol, butanol, and ethanol, as well as in acetone and ethyl acetate, though it does not dissolve in benzene or oils. Under standard conditions, it is stable but decomposes when heated, releasing toxic fumes of nitrogen oxides and chlorine.With antibiotic capabilities, chloramphenicol is incorporated into chemical and pharmaceutical processes, especially in the development and formulation of drugs. As a member of the alcohol family, it plays a crucial role in creating medications for treating bacterial infections, including eye conditions like conjunctivitis and otitis externa, as well as systemic diseases such as typhoid and cholera. It. functions by inhibiting bacterial protein synthesis, serving as an effective antimicrobial agent against infection-causing bacteria.
Market Drivers:
The market drivers for chloramphenicol are primarily its effectiveness in treating multi-resistant bacterial infections and its importance in veterinary medicine. As bacterial resistance to common antibiotics increases globally, the demand for broad-spectrum antibiotics like chloramphenicol, which can still effectively treat certain resistant strains, rises. Additionally, its relatively low cost compared to newer antibiotics makes it a valuable option in developing countries or under-resourced healthcare settings where cost-effective treatments are crucial. In veterinary medicine, chloramphenicol is used to treat a variety of infections in pets and livestock, further driving its demand. However, its use in animals intended for human consumption is restricted in many countries due to potential residual effects. The need for effective treatment options for severe and drug-resistant infections, both in humans and animals, continues to sustain the market for chloramphenicol.
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