The latest report titled “Artesunate Production” by Procurement Resource, a global procurement research and consulting firm, provides an in-depth cost analysis of the production process of Artesunate.
Procurement Resource study is based on the latest prices and other economic data available. It also offers additional analysis of the report with detailed breakdown of all cost components (capital investment details, production cost details, economics for another plant location, dynamic cost model). In addition, the report incorporates the production process with detailed process and material flow, capital investment, operating costs along with financial expenses and depreciation charges.
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Procurement Resource’s detailed report describes the stepwise consumption of material and utilities along with a detailed process flow diagram. Furthermore, the study assesses the latest developments within the industry that might influence Artesunate production cost, looking into capacity expansions, plant turnarounds, mergers, acquisitions, and investments.
Procurement Resource Assessment of Artesunate Production Process:
- From Artemisinin: This report presents the detailed production methodology and cost analysis of Artesunate industrial production across Artesunate manufacturing plants. The process starts by reacting artemisinin with a reducing agent like sodium borohydride or potassium borohydride. This step is followed by an esterification reaction. Subsequently, the intermediate product is esterified using succinic anhydride, culminating in the creation of artesunate as the end product.
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Product Definition:
Artesunate, a white crystalline powder with the chemical formula C19H28O8, consists of carbon, hydrogen, and oxygen atoms, and has a molecular weight of 384.4 g/mol. With a melting point between 131-135 °C, this water-soluble compound displays good solubility in water but is less soluble in neutral or acidic conditions. Derived from artemisinin, artesunate can dissolve in organic solvents such as ethanol, methanol, isopropanol, dimethyl sulfoxide, and dimethyl formamide, and has moderate solubility in aqueous buffers. As a key antimalarial drug, artesunate is employed in treating malaria but is not used for prevention. Available as injections and oral tablets or capsules, it should be administered under medical guidance. Artesunate targets malaria parasites within red blood cells, impacting various body systems in the process. Approved by the FDA, it’s a first-line treatment for severe malaria in both children and adults, demonstrating its effectiveness as a critical healthcare intervention.
Market Drivers:
The market for artesunate is primarily driven by its effectiveness as an antimalarial drug, crucial in regions with high malaria prevalence. The global fight against malaria, supported by international health organizations like the World Health Organization (WHO), pushes the demand for effective treatments, positioning artesunate as a key medication due to its rapid action against Plasmodium parasites. The increasing incidence of malaria, especially in tropical and subtropical areas, further propels the need for reliable and fast-acting antimalarial drugs. Additionally, artesunate’s inclusion in national and international treatment guidelines as a recommended treatment for severe malaria bolsters its market presence. The pharmaceutical development of more accessible and easy-to-administer forms of artesunate, such as oral and injectable formulations, also contributes to its market growth. However, ongoing research into resistance patterns and the continuous effort to improve malaria treatment protocols could influence market dynamics.
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