The latest report titled “Amiodarone Production” by Procurement Resource, a global procurement research and consulting firm, provides an in-depth cost analysis of the production process of Amiodarone.
Procurement Resource study is based on the latest prices and other economic data available. It also offers additional analysis of the report with detailed breakdown of all cost components (capital investment details, production cost details, economics for another plant location, dynamic cost model). In addition, the report incorporates the production process with detailed process and material flow, capital investment, operating costs along with financial expenses and depreciation charges.
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Procurement Resource’s detailed report describes the stepwise consumption of material and utilities along with a detailed process flow diagram. Furthermore, the study assesses the latest developments within the industry that might influence Amiodarone production cost, looking into capacity expansions, plant turnarounds, mergers, acquisitions, and investments.
Procurement Resource Assessment of Amiodarone Production Process:
From Benzofuran: This report presents the detailed production methodology and cost analysis of Amiodarone industrial production across Amiodarone manufacturing plants. The synthesis of amiodarone is a complex chemical process involving multiple reactions among various compounds. Initially, benzofuran is acylated with butyric acid anhydride in an acidic environment, specifically using phosphoric acid. This step produces 2-butyroylbenzofuran. This compound is then reduced using hydrazine hydrate, resulting in 2-butylbenzofurane. Following this, 2-butylbenzofurane is subjected to a reaction with 4-methoxy benzoic acid chloride, leading to its acetylation and the formation of 2-butyl-3-(4-methoxy benzoyl) benzofuran. This compound is then demethylated in a reaction with pyridine hydrochloride, yielding 2-butyl-3-(4-hydroxy-benzoyl)-benzofuran. The next step involves the iodization of this compound in the presence of potassium iodide, producing -butyl-3-benzofuranyl-4-(2-hydroxy-3,5-diiodophenyl) ketone as an intermediate. Finally, this intermediate is reacted with 2-diethylaminoethylchloride, culminating in the synthesis of amiodarone.
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Product Definition:
Amiodarone, a class III antiarrhythmic medication, has a complex composition with a formula of C25H29I2NO3 and a molecular weight of 645.3 g/mol. Characterized by a crystalline solid form and white color, it melts around 156 °C. While insoluble in water, it dissolves in solvents like methanol, is slightly soluble in ethanol, and fully soluble in chloropharm but not in ether. Positioned within the benzofuran family, amiodarone contains a butyl group and a 4-[2-(diethylamino)ethoxy]-3,5-diiodobenzoyl group, indicating its sensitivity to light and heat. Approved by the FDA for treating irregular heart rhythms, it moderates heart rate by damping excessive electrical signals, primarily used for severe arrhythmias like ventricular tachycardia and atrial fibrillation. Despite its effectiveness, overdose risks make prescription adherence crucial. Amiodarone’s base is also pivotal in creating derivatives like amiodarone hydrochloride, another significant cardiovascular therapy.
Market Drivers:
The demand for amiodarone in the global market is propelled by its significant role as an FDA-approved cardiovascular medication. Its proven efficacy in managing critical heart conditions, such as life-threatening arrhythmias, has cemented its status as a key player in the pharmaceutical and medical fields. This utility not only enhances its consumption but also boosts its importance within these sectors. Additionally, amiodarone’s value extends to the chemical industry as a foundational component for producing its medical derivatives, like amiodarone hydrochloride. This dual role as both a direct therapeutic agent and a precursor for other beneficial compounds underlines its critical impact on market demand, securing its position as a sought-after commodity in healthcare and chemical manufacturing.
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